Hepatic damage caused by long-term high cholesterol intake induces a dysfunctional restorative macrophage population in experimental NASH

Hepatic damage caused by long-term high cholesterol intake induces a dysfunctional restorative macrophage population in experimental NASH

Excessive dietary cholesterol is preferentially stored in the liver, favoring the development of nonalcoholic steatohepatitis (NASH), characterized by progressive hepatic inflammation and fibrosis. Emerging evidence indicates a critical contribution of hepatic macrophages to NASH severity. However,...

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Bibliographic Details
Main Authors: Ana C. Maretti-Mira, Matthew P. Salomon, Angela M. Hsu, Gary C. Kanel, Lucy Golden-Mason
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
nonalcoholic fatty liver disease (NAFLD)
Kupffer cells
tissue macrophages
RNAseq
innate immunity
cholesterol
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.968366/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.968366/full

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