Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus

Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus

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Chronic hepatitis B (CHB) is a global health care challenge and a major cause of liver disease. To find new therapeutic avenues with a potential to functionally cure chronic Hepatitis B virus (HBV) infection, we performed a focused screen of epigenetic modifiers to identify potential inhibitors of r...

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Bibliographic Details
Main Authors: Sarah A. Gilmore, Danny Tam, Tara L. Cheung, Chelsea Snyder, Julie Farand, Ryan Dick, Mike Matles, Joy Y. Feng, Ricardo Ramirez, Li Li, Helen Yu, Yili Xu, Dwight Barnes, Gregg Czerwieniec, Katherine M. Brendza, Todd C. Appleby, Gabriel Birkus, Madeleine Willkom, Tetsuya Kobayashi, Eric Paoli, Marc Labelle, Thomas Boesen, Chin H. Tay, William E. Delaney, Gregory T. Notte, Uli Schmitz, Becket Feierbach
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728921/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9728921/?tool=EBI

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