The anterior gradient homologue 2 (AGR2) co-localises with the glucose-regulated protein 78 (GRP78) in cancer stem cells, and is critical for the survival and drug resistance of recurrent glioblastoma: in situ and in vitro analyses

The anterior gradient homologue 2 (AGR2) co-localises with the glucose-regulated protein 78 (GRP78) in cancer stem cells, and is critical for the survival and drug resistance of recurrent glioblastoma: in situ and in vitro analyses

Abstract Background Glioblastomas (GBs) are characterised as one of the most aggressive primary central nervous system tumours (CNSTs). Single-cell sequencing analysis identified the presence of a highly heterogeneous population of cancer stem cells (CSCs). The proteins anterior gradient homologue 2...

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Bibliographic Details
Main Authors: Deema Hussein, Reem Alsereihi, Abdulla Ahmed A. Salwati, Rinad Algehani, Alazouf Alhowity, Ahmed M. Al-Hejin, Hans-Juergen Schulten, Saleh Baeesa, Mohammed Bangash, Fahad Alghamdi, Richard Cross, Torki Al Zughaibi, Mohamad Saka, Adeel Chaudhary, Adel Abuzenadah
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Cancer Cell International
Subjects:
Glioblastoma
Cancer stem cells (CSCs)
Anterior gradient homologue 2 (AGR2)
Glucose-regulated protein 78 (GRP78)
Drug resistance
Online Access:https://doi.org/10.1186/s12935-022-02814-5

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https://doi.org/10.1186/s12935-022-02814-5

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