Phosphorylation of serine 248 of C/EBPα is dispensable for myelopoiesis but its disruption leads to a low penetrant myeloid disorder with long latency.

Phosphorylation of serine 248 of C/EBPα is dispensable for myelopoiesis but its disruption leads to a low penetrant myeloid disorder with long latency.

<h4>Background</h4>Transcription factors play a key role in lineage commitment and differentiation of stem cells into distinct mature cells. In hematopoiesis, they regulate lineage-specific gene expression in a stage-specific manner through various physical and functional interactions wi...

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Bibliographic Details
Main Authors: Marie S Hasemann, Mikkel B Schuster, Anne-Katrine Frank, Kim Theilgaard-Mönch, Thomas Å Pedersen, Claus Nerlov, Bo T Porse
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22715416/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22715416/?tool=EBI

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