Dietary curcumin enhances insulin clearance in diet-induced obese mice via regulation of hepatic PI3K-AKT axis and IDE, and preservation of islet integrity

Dietary curcumin enhances insulin clearance in diet-induced obese mice via regulation of hepatic PI3K-AKT axis and IDE, and preservation of islet integrity

Abstract Background Although type 2 diabetes mellitus (T2DM) is primarily characterized by sustained high levels of circulating glucose, other factors, such as obesity, chronic inflammation, fatty liver, and islet dysfunction significantly contribute to the development of this disease. To date, curc...

Full description

Bibliographic Details
Main Authors: Yoo Kim, Michael Rouse, Isabel González-Mariscal, Josephine M. Egan, Jennifer F. O’Connell
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Nutrition & Metabolism
Subjects:
Curcumin
Insulin sensitivity
Phosphoinositide 3-kinase (PI3K)
Insulin degrading enzyme (IDE)
Hepatic insulin signaling pathway
Islet integrity
Online Access:http://link.springer.com/article/10.1186/s12986-019-0377-0

Internet

http://link.springer.com/article/10.1186/s12986-019-0377-0

Similar Items