NS5 Conservative Site Is Required for Zika Virus to Restrict the RIG-I Signaling

NS5 Conservative Site Is Required for Zika Virus to Restrict the RIG-I Signaling

During host–virus co-evolution, cells develop innate immune systems to inhibit virus invasion, while viruses employ strategies to suppress immune responses and maintain infection. Here, we reveal that Zika virus (ZIKV), a re-emerging arbovirus causing public concerns and devastating complications, r...

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Bibliographic Details
Main Authors: Aixin Li, Wenbiao Wang, Yingchong Wang, Keli Chen, Feng Xiao, Dingwen Hu, Lixia Hui, Weiyong Liu, Yuqian Feng, Geng Li, Qiuping Tan, Yingle Liu, Kailang Wu, Jianguo Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
IRF3
IFN-β
methyltransferase
NS5
RIG-I
ubiquitination
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00051/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00051/full

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