Activation of dopamine receptor D1 promotes osteogenic differentiation and reduces glucocorticoid-induced bone loss by upregulating the ERK1/2 signaling pathway

Activation of dopamine receptor D1 promotes osteogenic differentiation and reduces glucocorticoid-induced bone loss by upregulating the ERK1/2 signaling pathway

Abstract Background The inhibition of osteogenic differentiation is a major factor in glucocorticoid-induced bone loss, but there is currently no effective treatment. Dopamine, a major neurotransmitter, transmits signals via five different seven-transmembrane G protein-coupled receptors termed D1 to...

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Bibliographic Details
Main Authors: Jie Zhu, Chengcheng Feng, Weicheng Zhang, Zhidong Wang, Mengdan Zhong, Wenkai Tang, Zhifang Wang, Haiwei Shi, Zhengyu Yin, Jiandong Shi, Yu Huang, Long Xiao, Dechun Geng, Zhirong Wang
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Molecular Medicine
Subjects:
Glucocorticoid-induced bone loss
D1R
Osteoblast
ERK1/2
Osteoporosis
Online Access:https://doi.org/10.1186/s10020-022-00453-0

Internet

https://doi.org/10.1186/s10020-022-00453-0

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