Ectopic OR1A1 activation ameliorates hepatic lipid deposition through AMPK/SREBP-1/FASN pathway by three monoterpenes

Ectopic OR1A1 activation ameliorates hepatic lipid deposition through AMPK/SREBP-1/FASN pathway by three monoterpenes

Ectopic olfactory receptors, such as OR1A1, are involved in the regulation of lipid metabolism homeostasis. In this study, we investigated the effects of three monoterpenes, (+)-limonene, (−)-carvone and thymol, upon hepatic lipid deposition. Oral administration of (+)-limonene, (−)-carvone and thym...

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Bibliographic Details
Main Authors: Shuwei Ke, Siyu Zhang, Dongsheng Liu, Tengjiao Zhao, Xiayan Lou, Sunying Cheng, Tingheng Zhu, Hanbing Li
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Journal of Functional Foods
Subjects:
Lipid metabolism
OR1A1
(+)-limonene
(−)-carvone
Thymol
FASN
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464624000999

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http://www.sciencedirect.com/science/article/pii/S1756464624000999

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