Senolysis of gemcitabine‐induced senescent human pancreatic cancer cells

Abstract Introduction Gemcitabine (GEM) is often used to treat pancreatic cancer. Many anti‐cancer drugs induce cancer cell death, but some cells survive after cell cycle arrest. Such a response to DNA damage is termed cellular senescence. Certain drugs, including the Bcl‐2‐family inhibitor ABT‐263,...

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Bibliographic Details
Main Authors: Mohammad Mahbubul Hoque, Yuichi Iida, Hitoshi Kotani, Mamoru Harada
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:Cancer Reports
Subjects:
Online Access:https://doi.org/10.1002/cnr2.2075