HNF4α ubiquitination mediated by Peli1 impairs FAO and accelerates pressure overload-induced myocardial hypertrophy

HNF4α ubiquitination mediated by Peli1 impairs FAO and accelerates pressure overload-induced myocardial hypertrophy

Abstract Impaired fatty acid oxidation (FAO) is a prominent feature of metabolic remodeling observed in pathological myocardial hypertrophy. Hepatocyte nuclear factor 4alpha (HNF4α) is closely associated with FAO in both cellular processes and disease conditions. Pellino 1 (Peli1), an E3 ligase cont...

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Bibliographic Details
Main Authors: Yuxing Hou, Pengxi Shi, Haiyang Du, Chenghao Zhu, Chao Tang, Linli Que, Guoqing Zhu, Li Liu, Qi Chen, Chuanfu Li, Guoqiang Shao, Yuehua Li, Jiantao Li
Format: Article
Language:English
Published: Nature Publishing Group 2024-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-06470-7

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https://doi.org/10.1038/s41419-024-06470-7

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