Discovery of Novel Epoxyketone Peptides as Lipase Inhibitors

Discovery of Novel Epoxyketone Peptides as Lipase Inhibitors

Obesity is the most common nutritional disorder in the developed world and is associated with important comorbidities. Pancreatic lipase (PL) inhibitors play a key role in the metabolism of human fat. A series of novel epoxyketones peptide derivatives were investigated for their pancreatic lipase in...

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Bibliographic Details
Main Authors: Jehad Almaliti, Muhammed Alzweiri, Momen Alhindy, Tamam Al-Helo, Ibrahim Daoud, Raghad Deknash, C. Benjamin Naman, Bashaer Abu-Irmaileh, Yasser Bustanji, Islam Hamad
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Molecules
Subjects:
lipase inhibitors
novel warhead
epoxyketone
dyslipidemia
obesity
peptide inhibitors
Online Access:https://www.mdpi.com/1420-3049/27/7/2261

Internet

https://www.mdpi.com/1420-3049/27/7/2261

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