TRIM33 loss in multiple myeloma is associated with genomic instability and sensitivity to PARP inhibitors

TRIM33 loss in multiple myeloma is associated with genomic instability and sensitivity to PARP inhibitors

Abstract Deletions of chromosome 1p (del(1p)) are a recurrent genomic aberration associated with poor outcome in Multiple myeloma (MM.) TRIM33, an E3 ligase and transcriptional co-repressor, is located within a commonly deleted region at 1p13.2. TRIM33 is reported to play a role in the regulation of...

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Bibliographic Details
Main Authors: Roisin M. McAvera, Jonathan J. Morgan, Ana B. Herrero, Ken I. Mills, Lisa J. Crawford
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Scientific Reports
Subjects:
Multiple myeloma
DNA damage response
Genomic instability
TRIM33
PARP
Online Access:https://doi.org/10.1038/s41598-024-58828-8

Internet

https://doi.org/10.1038/s41598-024-58828-8

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