Synthesis and Hybrid SAR Property Modeling of Novel Cholinesterase Inhibitors

Synthesis and Hybrid SAR Property Modeling of Novel Cholinesterase Inhibitors

A library of novel 4-{[(benzyloxy)carbonyl]amino}-2-hydroxybenzoic acid amides was designed and synthesized in order to provide potential acetyl- and butyrylcholinesterase (AChE/BChE) inhibitors; the in vitro inhibitory profile and selectivity index were specified. Benzyl(3-hydroxy-4-{[2-(trifluorom...

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Bibliographic Details
Main Authors: Jiri Kos, Violetta Kozik, Dominika Pindjakova, Timotej Jankech, Adam Smolinski, Sarka Stepankova, Jan Hosek, Michal Oravec, Josef Jampilek, Andrzej Bak
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
4-aminosalicylanilides
carbamate synthesis
lipophilicity
cholinesterase inhibition
CoMSA
molecular docking
Online Access:https://www.mdpi.com/1422-0067/22/7/3444

Internet

https://www.mdpi.com/1422-0067/22/7/3444

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