Acute expression of human APOBEC3B in mice results in RNA editing and lethality

Acute expression of human APOBEC3B in mice results in RNA editing and lethality

Abstract Background RNA editing has been described as promoting genetic heterogeneity, leading to the development of multiple disorders, including cancer. The cytosine deaminase APOBEC3B is implicated in tumor evolution through DNA mutation, but whether it also functions as an RNA editing enzyme has...

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Bibliographic Details
Main Authors: Alicia Alonso de la Vega, Nuri Alpay Temiz, Rafail Tasakis, Kalman Somogyi, Lorena Salgueiro, Eleni Zimmer, Maria Ramos, Alberto Diaz-Jimenez, Sara Chocarro, Mirian Fernández-Vaquero, Bojana Stefanovska, Eli Reuveni, Uri Ben-David, Albrecht Stenzinger, Tanja Poth, Mathias Heikenwälder, Nina Papavasiliou, Reuben S. Harris, Rocio Sotillo
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Genome Biology
Subjects:
APOBEC3B
RNA editing
Mutations
Mouse models
DNA damage
Online Access:https://doi.org/10.1186/s13059-023-03115-4

Internet

https://doi.org/10.1186/s13059-023-03115-4

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