Prolonged epigenomic and synaptic plasticity alterations following single exposure to a psychedelic in mice

Prolonged epigenomic and synaptic plasticity alterations following single exposure to a psychedelic in mice

Summary: Clinical evidence suggests that rapid and sustained antidepressant action can be attained with a single exposure to psychedelics. However, the biological substrates and key mediators of psychedelics’ enduring action remain unknown. Here, we show that a single administration of the psychedel...

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Bibliographic Details
Main Authors: Mario de la Fuente Revenga, Bohan Zhu, Christopher A. Guevara, Lynette B. Naler, Justin M. Saunders, Zirui Zhou, Rudy Toneatti, Salvador Sierra, Jennifer T. Wolstenholme, Patrick M. Beardsley, George W. Huntley, Chang Lu, Javier González-Maeso
Format: Article
Language:English
Published: Elsevier 2021-10-01
Series:Cell Reports
Subjects:
psychedelics
hallucinogens
synaptic plasticity
epigenomics
serotonin (5-HT)
5-HT2A receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721013000

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http://www.sciencedirect.com/science/article/pii/S2211124721013000

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