Botulinum toxin type A alleviates neuropathic pain and suppresses inflammatory cytokines release from microglia by targeting TLR2/MyD88 and SNAP23

Botulinum toxin type A alleviates neuropathic pain and suppresses inflammatory cytokines release from microglia by targeting TLR2/MyD88 and SNAP23

Abstract Background Botulinum toxin type A (BTX-A) was considered to be a new potential drug for neuropathic pain (NP) treatment. Results In vivo, BTX-A attenuated chronic compression injury (CCI)-induced pain in rats, and reduced production of pro-inflammatory factors. The inhibition of BTX-A to ex...

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Bibliographic Details
Main Authors: Xuan Wang, Sheng Tian, Hansen Wang, Pan Liu, Heqing Zheng, Lanxiang Wu, Qian Liu, Wei Wu
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Cell & Bioscience
Subjects:
Neuropathic pain
Botulinum toxin type A
Microglia
Synaptosome associated protein 23
Online Access:https://doi.org/10.1186/s13578-020-00501-4

Internet

https://doi.org/10.1186/s13578-020-00501-4

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