Disrupted presynaptic nectin1-based neuronal adhesion in the entorhinal-hippocampal circuit contributes to early-life stress-induced memory deficits

Abstract The cell adhesion molecule nectin3 and its presynaptic partner nectin1 have been linked to early-life stress-related cognitive disorders, but how the nectin1-nectin3 system contributes to stress-induced neuronal, circuit, and cognitive abnormalities remains to be studied. Here we show that...

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Bibliographic Details
Main Authors: Chen Wu, Qian Gong, Xue Xu, Ping Fang, Chi Wang, Jing-Ying Yu, Xing-Xing Wang, San-Hua Fang, Wen-Juan Chen, Hui-Fang Lou, Yu-Hui Liu, Liang Wang, Yi-Jun Liu, Wei Chen, Xiao-Dong Wang
Format: Article
Language:English
Published: Nature Publishing Group 2022-04-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-022-01908-y