Cdk5 Is Essential for Amphetamine to Increase Dendritic Spine Density in Hippocampal Pyramidal Neurons

Cdk5 Is Essential for Amphetamine to Increase Dendritic Spine Density in Hippocampal Pyramidal Neurons

Psychostimulant drugs of abuse increase dendritic spine density in reward centers of the brain. However, little is known about their effects in the hippocampus, where activity-dependent changes in the density of dendritic spine are associated with learning and memory. Recent reports suggest that Cdk...

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Bibliographic Details
Main Authors: Soledad Ferreras, Guillermo Fernández, Víctor Danelon, María V. Pisano, Luján Masseroni, Christopher A. Chapleau, Favio A. Krapacher, Estela C. Mlewski, Daniel H. Mascó, Carlos Arias, Lucas Pozzo-Miller, María G. Paglini
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
amphetamine
hippocampus
dendritic spines
Cdk5/p25
calpain
organotypic slice cultures
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00372/full

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http://journal.frontiersin.org/article/10.3389/fncel.2017.00372/full

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