Plant Polyphenols and Exendin-4 Prevent Hyperactivity and TNF-α Release in LPS-Treated In vitro Neuron/Astrocyte/Microglial Networks

Plant Polyphenols and Exendin-4 Prevent Hyperactivity and TNF-α Release in LPS-Treated In vitro Neuron/Astrocyte/Microglial Networks

Increasing evidence supports a decisive role for neuroinflammation in the neurodegenerative process of several central nervous system (CNS) disorders. Microglia are essential mediators of neuroinflammation and can regulate a broad spectrum of cellular responses by releasing reactive oxygen intermedi...

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Bibliographic Details
Main Authors: Francesca Gullo, Michela Ceriani, Alessia D'Aloia, Enzo Wanke, Andrew Constanti, Barbara Costa, Marzia Lecchi
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Neuroscience
Subjects:
sterile inflammation
LPS
TNF-α
GLP-1
plant polyphenols
exendin-4 (EX-4)
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2017.00500/full

Internet

http://journal.frontiersin.org/article/10.3389/fnins.2017.00500/full

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