Type 2 cytokines sensitize human sensory neurons to itch-associated stimuli

Type 2 cytokines sensitize human sensory neurons to itch-associated stimuli

IntroductionChronic itch is a central symptom of atopic dermatitis. Cutaneous afferent neurons express receptors interleukins (IL)-4, IL-13, and IL-33, which are type 2 cytokines that are elevated in atopic dermatitis. These neuronal cytokine receptors were found to be required in several murine mod...

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Bibliographic Details
Main Authors: Madison R. Mack, Yannick Miron, Fanny Chen, Paul E. Miller, Annie Zhang, Andrew Korotzer, Daniel Richman, Paul J. Bryce
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
type 2 cytokines
IL-4
IL-13
IL-33
atopic dermatitis
chronic itch
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1258823/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2023.1258823/full

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