VCAM-1 Targeted Lipopolyplexes as Vehicles for Efficient Delivery of shRNA-Runx2 to Osteoblast-Differentiated Valvular Interstitial Cells; Implications in Calcific Valve Disease Treatment

VCAM-1 Targeted Lipopolyplexes as Vehicles for Efficient Delivery of shRNA-Runx2 to Osteoblast-Differentiated Valvular Interstitial Cells; Implications in Calcific Valve Disease Treatment

Calcific aortic valve disease (CAVD) is a progressive inflammatory disorder characterized by extracellular matrix remodeling and valvular interstitial cells (VIC) osteodifferentiation leading to valve leaflets calcification and impairment movement. Runx2, the master transcription factor involved in...

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Bibliographic Details
Main Authors: Geanina Voicu, Daniela Rebleanu, Cristina Ana Mocanu, Gabriela Tanko, Ionel Droc, Cristina Mariana Uritu, Mariana Pinteala, Ileana Manduteanu, Maya Simionescu, Manuela Calin
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:International Journal of Molecular Sciences
Subjects:
calcific aortic valve disease
lipopolyplexes
Runx2
shRNA
valvular interstitial cells
VCAM-1
Online Access:https://www.mdpi.com/1422-0067/23/7/3824

Internet

https://www.mdpi.com/1422-0067/23/7/3824

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