Theacrine alleviates sepsis-induced acute kidney injury by repressing the activation of NLRP3/Caspase-1 inflammasome

Theacrine alleviates sepsis-induced acute kidney injury by repressing the activation of NLRP3/Caspase-1 inflammasome

Acute kidney injury (AKI) is a frequent and serious complication of sepsis, which results in a rapid decline of kidney function. Currently, there are no curative therapies for AKI. Theacrine is a purine alkaloid and exerts significant role in regulating inflammation, oxidative stress, and mood eleva...

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Bibliographic Details
Main Authors: Maoxian Yang, Peng Shen, Longsheng Xu, Min Kong, Congcong Yu, Yunchao Shi
Format: Article
Language:English
Published: PeerJ Inc. 2022-10-01
Series:PeerJ
Subjects:
Acute kidney injury
Theacrine
NLRP3
Inflammation
Sepsis
Online Access:https://peerj.com/articles/14109.pdf

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