Detection and genomic analysis of BRAF fusions in Juvenile Pilocytic Astrocytoma through the combination and integration of multi-omic data

Detection and genomic analysis of BRAF fusions in Juvenile Pilocytic Astrocytoma through the combination and integration of multi-omic data

Abstract Background Juvenile Pilocytic Astrocytomas (JPAs) are one of the most common pediatric brain tumors, and they are driven by aberrant activation of the mitogen-activated protein kinase (MAPK) signaling pathway. RAF-fusions are the most common genetic alterations identified in JPAs, with the...

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Bibliographic Details
Main Authors: Melissa Zwaig, Audrey Baguette, Bo Hu, Michael Johnston, Hussein Lakkis, Emily M. Nakada, Damien Faury, Nikoleta Juretic, Benjamin Ellezam, Alexandre G. Weil, Jason Karamchandani, Jacek Majewski, Mathieu Blanchette, Michael D. Taylor, Marco Gallo, Claudia L. Kleinman, Nada Jabado, Jiannis Ragoussis
Format: Article
Language:English
Published: BMC 2022-12-01
Series:BMC Cancer
Subjects:
Juvenile Pilocytic Astrocytoma
BRAF fusions
Linked-reads
Hi-C
RNA sequencing
Single-cell RNA sequencing
Online Access:https://doi.org/10.1186/s12885-022-10359-z

Internet

https://doi.org/10.1186/s12885-022-10359-z

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