Temporal Profile of Kynurenine Pathway Metabolites in a Rodent Model of Autosomal Recessive Polycystic Kidney Disease

Temporal Profile of Kynurenine Pathway Metabolites in a Rodent Model of Autosomal Recessive Polycystic Kidney Disease

Autosomal recessive polycystic kidney disease (ARPKD) is an early onset genetic disorder characterized by numerous renal cysts resulting in end stage renal disease. Our study aimed to determine if metabolic reprogramming and tryptophan (Trp) metabolism via the kynurenine pathway (KP) is a critical d...

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Bibliographic Details
Main Authors: Ananda Staats Pires, Shabarni Gupta, Sean A Barton, Roshana Vander Wall, Vanessa Tan, Benjamin Heng, Jacqueline K Phillips, Gilles J Guillemin
Format: Article
Language:English
Published: SAGE Publishing 2022-10-01
Series:International Journal of Tryptophan Research
Online Access:https://doi.org/10.1177/11786469221126063

Internet

https://doi.org/10.1177/11786469221126063

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