Analysis of SHIP1 expression and activity in Crohn's disease patients.

Analysis of SHIP1 expression and activity in Crohn's disease patients.

SH2 domain containing inositol-5-phosphatase (SHIP1) is an important modulator of innate and adaptive immunity. In mice, loss of SHIP1 provokes severe ileitis resembling Crohn's disease (CD), as a result of deregulated immune responses, altered cytokine production and intestinal fibrosis. Recen...

Full description

Bibliographic Details
Main Authors: Rajesh Somasundaram, Sandra Fernandes, Jasper J Deuring, Colin de Haar, Ernst J Kuipers, Lauran Vogelaar, Frank A Middleton, C Janneke van der Woude, Maikel P Peppelenbosch, William G Kerr, Gwenny M Fuhler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5540589?pdf=render

Internet

http://europepmc.org/articles/PMC5540589?pdf=render

Similar Items