Influence and interaction of resting state functional magnetic resonance and tryptophan hydroxylase-2 methylation on short-term antidepressant drug response

Influence and interaction of resting state functional magnetic resonance and tryptophan hydroxylase-2 methylation on short-term antidepressant drug response

Abstract Background Most antidepressants have been developed on the basis of the monoamine deficiency hypothesis of depression, in which neuronal serotonin (5-HT) plays a key role. 5-HT biosynthesis is regulated by the rate-limiting enzyme tryptophan hydroxylase-2 (TPH2). TPH2 methylation is correla...

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Bibliographic Details
Main Authors: Tingting Tan, Zhi Xu, Chenjie Gao, Tian Shen, Lei Li, Zimu Chen, Lei Chen, Min Xu, Bingwei Chen, Jiacheng Liu, Zhijun Zhang, Yonggui Yuan
Format: Article
Language:English
Published: BMC 2022-03-01
Series:BMC Psychiatry
Subjects:
Major Depressive Disorder
Antidepressants
DNA methylation
TPH2
Resting-state functional MRI
Online Access:https://doi.org/10.1186/s12888-022-03860-z

Internet

https://doi.org/10.1186/s12888-022-03860-z

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