Identification of COX4I2 as a hypoxia-associated gene acting through FGF1 to promote EMT and angiogenesis in CRC

Identification of COX4I2 as a hypoxia-associated gene acting through FGF1 to promote EMT and angiogenesis in CRC

Abstract Background Current evidence suggests that the hypoxic tumor microenvironment further aggravates tumor progression, leading to poor therapeutic outcomes. There is as yet no biomarker capable of evaluating the hypoxic state of the tumor. The cytochrome c oxidase (COX) subunit is crucial to th...

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Bibliographic Details
Main Authors: Jie-pin Li, Yuan-jie Liu, Shu-hong Zeng, Hai-jian Gao, Yu-gen Chen, Xi Zou
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Cellular & Molecular Biology Letters
Subjects:
Colorectal cancer
COX4I2
Fibroblast growth factor 1
Epithelial–mesenchymal transition
Angiogenesis
Cancer-associated fibroblasts
Online Access:https://doi.org/10.1186/s11658-022-00380-2

Internet

https://doi.org/10.1186/s11658-022-00380-2

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