Erk1/2 Inactivation-Induced c-Jun Degradation Is Regulated by Protein Phosphatases, UBE2d3, and the C-Terminus of c-Jun

Erk1/2 Inactivation-Induced c-Jun Degradation Is Regulated by Protein Phosphatases, UBE2d3, and the C-Terminus of c-Jun

Constitutive photomorphogenic 1 (COP1) is the ubiquitin E3 ligase that mediates degradation of c-Jun protein upon Erk1/2 inactivation. It remains unknown how this protein degradation pathway is regulated. In this study, we investigated the roles of protein phosphatases, ubiquitin-conjugating E2 enzy...

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Bibliographic Details
Main Authors: Weiming Ouyang, David M. Frucht
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:International Journal of Molecular Sciences
Subjects:
ubiquitin E3 ligase
COP1
protein phosphatase
UBE2d3
c-Jun
protein degradation
Online Access:https://www.mdpi.com/1422-0067/22/8/3889

Internet

https://www.mdpi.com/1422-0067/22/8/3889

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