Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the TDP-43 G298S ALS mouse model

Longitudinal diffusion tensor magnetic resonance imaging analysis at the cohort level reveals disturbed cortical and callosal microstructure with spared corticospinal tract in the TDP-43 G298S ALS mouse model

Abstract Background In vivo diffusion tensor imaging (DTI) of the mouse brain was used to identify TDP-43 associated alterations in a mouse model for amyotrophic lateral sclerosis (ALS). Methods Ten mice with TDP-43 G298S overexpression under control of the Thy1.2 promoter and 10 wild type (wt) unde...

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Bibliographic Details
Main Authors: Hans-Peter Müller, David Brenner, Francesco Roselli, Diana Wiesner, Alireza Abaei, Martin Gorges, Karin M. Danzer, Albert C. Ludolph, William Tsao, Philip C. Wong, Volker Rasche, Jochen H. Weishaupt, Jan Kassubek
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Translational Neurodegeneration
Subjects:
Diffusion tensor imaging
Amyotrophic lateral sclerosis
Mutant TDP-43
Fiber tracking
Mouse brain
Online Access:http://link.springer.com/article/10.1186/s40035-019-0163-y

Internet

http://link.springer.com/article/10.1186/s40035-019-0163-y

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