Immunomodulatory LncRNA on antisense strand of ICAM-1 augments SARS-CoV-2 infection-associated airway mucoinflammatory phenotype

Immunomodulatory LncRNA on antisense strand of ICAM-1 augments SARS-CoV-2 infection-associated airway mucoinflammatory phenotype

Summary: Noncoding RNAs are important regulators of mucoinflammatory response, but little is known about the contribution of airway long noncoding RNAs (lncRNAs) in COVID-19. RNA-seq analysis showed a more than 4-fold increased expression of IL-6, ICAM-1, CXCL-8, and SCGB1A1 inflammatory factors; MU...

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Bibliographic Details
Main Authors: Dinesh Devadoss, Arpan Acharya, Marko Manevski, Dominika Houserova, Michael D. Cioffi, Kabita Pandey, Madhavan Nair, Prem Chapagain, Mehdi Mirsaeidi, Glen M. Borchert, Siddappa N. Byrareddy, Hitendra S. Chand
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:iScience
Subjects:
Molecular biology
Molecular mechanism of gene regulation
Immunology
Virology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222009579

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http://www.sciencedirect.com/science/article/pii/S2589004222009579

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