Pan-cancer and single-cell analysis reveal dual roles of lymphocyte activation gene-3 (LAG3) in cancer immunity and prognosis

Pan-cancer and single-cell analysis reveal dual roles of lymphocyte activation gene-3 (LAG3) in cancer immunity and prognosis

Abstract Lymphocyte activating gene-3 (LAG3) is a distinctive T cell co-receptor that is expressed on the surface of lymphocytes. It plays a special inhibitory immune checkpoint role due to its unique domain and signaling pattern. Our aim is to explore the correlation between LAG3 in cancers and phy...

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Bibliographic Details
Main Authors: Yongfeng Wang, Yanzong Zhao, Guangming Zhang, Yifeng Lin, Chunling Fan, Hui Wei, Shude Chen, Ling Guan, Kan Liu, Shenhan Yu, Liangyin Fu, Jing Zhang, Yuan Yuan, Jin He, Hui Cai
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Scientific Reports
Subjects:
LAG3
Immune checkpoint
CD8+T cell
Pan-cancer
Prognosis
Online Access:https://doi.org/10.1038/s41598-024-74808-4

Internet

https://doi.org/10.1038/s41598-024-74808-4

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