Mangiferin Improves Hepatic Lipid Metabolism Mainly Through Its Metabolite-Norathyriol by Modulating SIRT-1/AMPK/SREBP-1c Signaling

Mangiferin Improves Hepatic Lipid Metabolism Mainly Through Its Metabolite-Norathyriol by Modulating SIRT-1/AMPK/SREBP-1c Signaling

Objective: Mangiferin (MGF) is a natural xanthone, with regulation effect on lipid metabolism. However, the molecular mechanism remains unclear. We purposed after oral administration, MGF is converted to its active metabolite(s), which contributes to the effects on lipid metabolism.Methods: KK-Ay mi...

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Bibliographic Details
Main Authors: Jian Li, Mengyang Liu, Haiyang Yu, Wei Wang, Lifeng Han, Qian Chen, Jingya Ruan, Shaoshi Wen, Yi Zhang, Tao Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-03-01
Series:Frontiers in Pharmacology
Subjects:
SIRT-1
AMPK
mangiferin
norathyriol
hepatic lipid metabolism
SREBP-1c
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00201/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00201/full

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