Parental age and gene expression profiles in individual human blastocysts

Abstract The epigenetic status of the genome changes dynamically from fertilization to implantation. In addition, the physiological environment during the process of gametogenesis, including parental age, may affect the epigenome of the embryo after fertilization. It is important to clarify the infl...

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Bibliographic Details
Main Authors: Kiyotaka Kawai, Tatsuya Harada, Tomonori Ishikawa, Rikikazu Sugiyama, Toshihiro Kawamura, Atsumi Yoshida, Osamu Tsutsumi, Fumitoshi Ishino, Toshiro Kubota, Takashi Kohda
Format: Article
Language:English
Published: Nature Portfolio 2018-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-018-20614-8