Interaction between Omeprazole and Gliclazide in Relation to CYP2C19 Phenotype

Interaction between Omeprazole and Gliclazide in Relation to CYP2C19 Phenotype

The antidiabetic drug gliclazide is partly metabolized by CYP2C19, the main enzyme involved in omeprazole metabolism. The aim of the study was to explore the interaction between omeprazole and gliclazide in relation to CYP2C19 phenotype using physiologically based pharmacokinetic (PBPK) modeling app...

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Bibliographic Details
Main Authors: Tanja Dujic, Sandra Cvijic, Amar Elezovic, Tamer Bego, Selma Imamovic Kadric, Maja Malenica, Alisa Elezovic, Ewan R. Pearson, Aida Kulo
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Journal of Personalized Medicine
Subjects:
omeprazole
gliclazide
CYP2C19
physiologically based pharmacokinetic modeling
drug–drug interaction
drug–drug–gene interaction
Online Access:https://www.mdpi.com/2075-4426/11/5/367

Internet

https://www.mdpi.com/2075-4426/11/5/367

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