PDK4 inhibits osteoarthritis progression by activating the PPAR pathway

Abstract Background Osteoarthritis (OA) is a degenerative joint disease caused by the deterioration of cartilage. However, the underlying mechanisms of OA pathogenesis remain elusive. Methods Hub genes were screened by bioinformatics analysis based on the GSE114007 and GSE169077 datasets. The Spragu...

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Bibliographic Details
Main Authors: Zhengnan Li, Lifeng Xie, Hui Zeng, Yaohong Wu
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Online Access:https://doi.org/10.1186/s13018-024-04583-5