The systemic renin-angiotensin system in COVID-19

The systemic renin-angiotensin system in COVID-19

Abstract SARS-CoV-2 gains cell entry via angiotensin-converting enzyme (ACE) 2, a membrane-bound enzyme of the “alternative” (alt) renin-angiotensin system (RAS). ACE2 counteracts angiotensin II by converting it to potentially protective angiotensin 1–7. Using mass spectrometry, we assessed key meta...

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Main Authors: Roman Reindl-Schwaighofer, Sebastian Hödlmoser, Oliver Domenig, Katharina Krenn, Farsad Eskandary, Simon Krenn, Christian Schörgenhofer, Benedikt Rumpf, Mario Karolyi, Marianna T. Traugott, Agnes Abrahamowicz, Viktoria Tinhof, Hannah Mayfurth, Vincent Rathkolb, Sebastian Mußnig, Lukas Schmölz, Roman Ullrich, Andreas Heinzel, Franz König, Christina Binder, Diana Bonderman, Robert Strassl, Elisabeth Puchhammer-Stöckl, Gregor Gorkiewicz, Judith H. Aberle, Bernd Jilma, Christoph Wenisch, Marko Poglitsch, Rainer Oberbauer, Alexander Zoufaly, Manfred Hecking
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-24628-1

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https://doi.org/10.1038/s41598-022-24628-1

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