SINEUP non-coding RNA activity depends on specific N6-methyladenosine nucleotides

SINEUP non-coding RNA activity depends on specific N6-methyladenosine nucleotides

SINEUPs are natural and synthetic antisense long non-coding RNAs (lncRNAs) selectively enhancing target mRNAs translation by increasing their association with polysomes. This activity requires two RNA domains: an embedded inverted SINEB2 element acting as effector domain, and an antisense region, th...

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Bibliographic Details
Main Authors: Bianca Pierattini, Sabrina D’Agostino, Carlotta Bon, Omar Peruzzo, Andrej Alendar, Azzurra Codino, Gloria Ros, Francesca Persichetti, Remo Sanges, Piero Carninci, Claudio Santoro, Stefano Espinoza, Paola Valentini, Luca Pandolfini, Stefano Gustincich
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Non-coding RNAs
SINEUP
lncRNA
RNA therapeutics
m6A
N6-methyladenosine
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253123000884

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http://www.sciencedirect.com/science/article/pii/S2162253123000884

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