Identification of Potent Zika Virus NS5 RNA-Dependent RNA Polymerase Inhibitors Combining Virtual Screening and Biological Assays

Identification of Potent Zika Virus NS5 RNA-Dependent RNA Polymerase Inhibitors Combining Virtual Screening and Biological Assays

The Zika virus (ZIKV) epidemic poses a significant threat to human health globally. Thus, there is an urgent need for developing effective anti-ZIKV agents. ZIKV non-structural protein 5 RNA-dependent RNA polymerase (RdRp), a viral enzyme for viral replication, has been considered an attractive drug...

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Bibliographic Details
Main Authors: Ying Chen, Xiangyin Chi, Hongjuan Zhang, Yu Zhang, Luyao Qiao, Jinwen Ding, Yanxing Han, Yuan Lin, Jiandong Jiang
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
Zika virus
RdRp
virtual screening
inhibitor
posaconazole
Online Access:https://www.mdpi.com/1422-0067/24/3/1900

Internet

https://www.mdpi.com/1422-0067/24/3/1900

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