miR-1323 suppresses bone mesenchymal stromal cell osteogenesis and fracture healing via inhibiting BMP4/SMAD4 signaling

miR-1323 suppresses bone mesenchymal stromal cell osteogenesis and fracture healing via inhibiting BMP4/SMAD4 signaling

Abstract Background Atrophic non-union fractures show no radiological evidence of callus formation within 3 months of fracture. microRNA dysregulation may underlie the dysfunctional osteogenesis in atrophic non-union fractures. Here, we aimed to analyze miR-1323 expression in human atrophic non-unio...

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Bibliographic Details
Main Authors: Hui Xie, Ming Liu, Yaofeng Jin, Haiqing Lin, Yushan Zhang, Song Zheng
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Fracture
Atrophic non-union
BMP4
SMAD4
miR-1323
Online Access:http://link.springer.com/article/10.1186/s13018-020-01685-8

Internet

http://link.springer.com/article/10.1186/s13018-020-01685-8

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