<i>In Vitro</i> Viral Evolution Identifies a Critical Residue in the Alphaherpesvirus Fusion Glycoprotein B Ectodomain That Controls gH/gL-Independent Entry

<i>In Vitro</i> Viral Evolution Identifies a Critical Residue in the Alphaherpesvirus Fusion Glycoprotein B Ectodomain That Controls gH/gL-Independent Entry

The class III fusion protein glycoprotein B (gB) drives membrane fusion during entry and spread of herpesviruses. To mediate fusion, gB requires activation by the conserved gH/gL complex by a poorly defined mechanism.

Bibliographic Details
Main Authors: Melina Vallbracht, Henriette Lötzsch, Barbara G. Klupp, Walter Fuchs, Benjamin Vollmer, Kay Grünewald, Marija Backovic, Felix A. Rey, Thomas C. Mettenleiter
Format: Article
Language:English
Published: American Society for Microbiology 2021-06-01
Series:mBio
Online Access:https://journals.asm.org/doi/10.1128/mBio.00557-21

Internet

https://journals.asm.org/doi/10.1128/mBio.00557-21

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