SphK1/S1P mediates TGF-β1-induced proliferation of pulmonary artery smooth muscle cells and its potential mechanisms

SphK1/S1P mediates TGF-β1-induced proliferation of pulmonary artery smooth muscle cells and its potential mechanisms

The upregulation of Sphingosine kinase 1 (SphK1) expression and accompanied sphingosine-1-phosphate (S1P) production have been reported to contribute to the proliferation of pulmonary artery smooth muscle cells (PASMC) and pulmonary arterial remodeling. However, the molecular mechanisms of SphK1/S1P...

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Bibliographic Details
Main Authors: Jian Wang, Wei Feng, Fangwei Li, Wenhua Shi, Cui Zhai, Shaojun Li, Yanting Zhu, Xin Yan, Qingting Wang, Lu Liu, Xinming Xie, Manxiang Li
Format: Article
Language:English
Published: Wiley 2018-12-01
Series:Pulmonary Circulation
Online Access:https://doi.org/10.1177/2045894018816977

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https://doi.org/10.1177/2045894018816977

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