iPla2β Deficiency Suppresses Hepatic ER UPR, Fxr, and Phospholipids in Mice Fed with MCD Diet, Resulting in Exacerbated Hepatic Bile Acids and Biliary Cell Proliferation

iPla2β Deficiency Suppresses Hepatic ER UPR, Fxr, and Phospholipids in Mice Fed with MCD Diet, Resulting in Exacerbated Hepatic Bile Acids and Biliary Cell Proliferation

<b>Background:</b> Group VIA calcium-independent phospholipase A2 (iPla2&#946;) regulates homeostasis and remodeling of phospholipids (PL). We previously showed that iPla2&#946;<sup>&#8722;/&#8722;</sup> mice fed with a methionine-choline-deficient diet (MCD)...

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Bibliographic Details
Main Authors: Yanan Ming, Xingya Zhu, Sabine Tuma-Kellner, Alexandra Ganzha, Gerhard Liebisch, Hongying Gan-Schreier, Walee Chamulitrat
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cells
Subjects:
PLA2G6
endoplasmic reticulum
phospholipids
bile acids
lean NASH
unfolded protein response
Online Access:https://www.mdpi.com/2073-4409/8/8/879

Internet

https://www.mdpi.com/2073-4409/8/8/879

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