Brain-protective mechanisms of autophagy associated circRNAs: Kick starting self-cleaning mode in brain cells via circRNAs as a potential therapeutic approach for neurodegenerative diseases
Altered autophagy is a hallmark of neurodegeneration but how autophagy is regulated in the brain and dysfunctional autophagy leads to neuronal death has remained cryptic. Being a key cellular waste-recycling and housekeeping system, autophagy is implicated in a range of brain disorders and altering...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Molecular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2022.1078441/full |
| _version_ | 1797951785253470208 |
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| author | Rabea Basri Faryal Mehwish Awan Burton B. Yang Burton B. Yang Burton B. Yang Usman Ayub Awan Ayesha Obaid Anam Naz Aqsa Ikram Suliman Khan Ijaz ul Haq Sadiq Noor Khan Muslim Bin Aqeel |
| author_facet | Rabea Basri Faryal Mehwish Awan Burton B. Yang Burton B. Yang Burton B. Yang Usman Ayub Awan Ayesha Obaid Anam Naz Aqsa Ikram Suliman Khan Ijaz ul Haq Sadiq Noor Khan Muslim Bin Aqeel |
| author_sort | Rabea Basri |
| collection | DOAJ |
| description | Altered autophagy is a hallmark of neurodegeneration but how autophagy is regulated in the brain and dysfunctional autophagy leads to neuronal death has remained cryptic. Being a key cellular waste-recycling and housekeeping system, autophagy is implicated in a range of brain disorders and altering autophagy flux could be an effective therapeutic strategy and has the potential for clinical applications down the road. Tight regulation of proteins and organelles in order to meet the needs of complex neuronal physiology suggests that there is distinct regulatory pattern of neuronal autophagy as compared to non-neuronal cells and nervous system might have its own separate regulator of autophagy. Evidence has shown that circRNAs participates in the biological processes of autophagosome assembly. The regulatory networks between circRNAs, autophagy, and neurodegeneration remains unknown and warrants further investigation. Understanding the interplay between autophagy, circRNAs and neurodegeneration requires a knowledge of the multiple steps and regulatory interactions involved in the autophagy pathway which might provide a valuable resource for the diagnosis and therapy of neurodegenerative diseases. In this review, we aimed to summarize the latest studies on the role of brain-protective mechanisms of autophagy associated circRNAs in neurodegenerative diseases (including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Spinal Muscular Atrophy, Amyotrophic Lateral Sclerosis, and Friedreich’s ataxia) and how this knowledge can be leveraged for the development of novel therapeutics against them. Autophagy stimulation might be potential one-size-fits-all therapy for neurodegenerative disease as per considerable body of evidence, therefore future research on brain-protective mechanisms of autophagy associated circRNAs will illuminate an important feature of nervous system biology and will open the door to new approaches for treating neurodegenerative diseases. |
| first_indexed | 2024-04-10T22:36:01Z |
| format | Article |
| id | doaj.art-43aaae3060434aff93bc89e2266ba90b |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-04-10T22:36:01Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-43aaae3060434aff93bc89e2266ba90b2023-01-16T13:52:18ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992023-01-011510.3389/fnmol.2022.10784411078441Brain-protective mechanisms of autophagy associated circRNAs: Kick starting self-cleaning mode in brain cells via circRNAs as a potential therapeutic approach for neurodegenerative diseasesRabea Basri0Faryal Mehwish Awan1Burton B. Yang2Burton B. Yang3Burton B. Yang4Usman Ayub Awan5Ayesha Obaid6Anam Naz7Aqsa Ikram8Suliman Khan9Ijaz ul Haq10Sadiq Noor Khan11Muslim Bin Aqeel12Department of Medical Lab Technology, The University of Haripur (UOH), Haripur, PakistanDepartment of Medical Lab Technology, The University of Haripur (UOH), Haripur, PakistanSunnybrook Health Sciences Centre, Sunnybrook Research Institute, Toronto, ON, CanadaDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, CanadaInstitute of Medical Sciences, University of Toronto, Toronto, ON, CanadaDepartment of Medical Lab Technology, The University of Haripur (UOH), Haripur, PakistanDepartment of Medical Lab Technology, The University of Haripur (UOH), Haripur, PakistanInstitute of Molecular Biology and Biotechnology (IMBB), The University of Lahore (UOL), Lahore, PakistanInstitute of Molecular Biology and Biotechnology (IMBB), The University of Lahore (UOL), Lahore, PakistanDepartment of Medical Lab Technology, The University of Haripur (UOH), Haripur, PakistanDepartment of Public Health and Nutrition, The University of Haripur (UOH), Haripur, PakistanDepartment of Medical Lab Technology, The University of Haripur (UOH), Haripur, PakistanDepartment of Medical Lab Technology, The University of Haripur (UOH), Haripur, PakistanAltered autophagy is a hallmark of neurodegeneration but how autophagy is regulated in the brain and dysfunctional autophagy leads to neuronal death has remained cryptic. Being a key cellular waste-recycling and housekeeping system, autophagy is implicated in a range of brain disorders and altering autophagy flux could be an effective therapeutic strategy and has the potential for clinical applications down the road. Tight regulation of proteins and organelles in order to meet the needs of complex neuronal physiology suggests that there is distinct regulatory pattern of neuronal autophagy as compared to non-neuronal cells and nervous system might have its own separate regulator of autophagy. Evidence has shown that circRNAs participates in the biological processes of autophagosome assembly. The regulatory networks between circRNAs, autophagy, and neurodegeneration remains unknown and warrants further investigation. Understanding the interplay between autophagy, circRNAs and neurodegeneration requires a knowledge of the multiple steps and regulatory interactions involved in the autophagy pathway which might provide a valuable resource for the diagnosis and therapy of neurodegenerative diseases. In this review, we aimed to summarize the latest studies on the role of brain-protective mechanisms of autophagy associated circRNAs in neurodegenerative diseases (including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Spinal Muscular Atrophy, Amyotrophic Lateral Sclerosis, and Friedreich’s ataxia) and how this knowledge can be leveraged for the development of novel therapeutics against them. Autophagy stimulation might be potential one-size-fits-all therapy for neurodegenerative disease as per considerable body of evidence, therefore future research on brain-protective mechanisms of autophagy associated circRNAs will illuminate an important feature of nervous system biology and will open the door to new approaches for treating neurodegenerative diseases.https://www.frontiersin.org/articles/10.3389/fnmol.2022.1078441/fullcircRNAsautophagyneurodegenerationnervous systemtherapeutics |
| spellingShingle | Rabea Basri Faryal Mehwish Awan Burton B. Yang Burton B. Yang Burton B. Yang Usman Ayub Awan Ayesha Obaid Anam Naz Aqsa Ikram Suliman Khan Ijaz ul Haq Sadiq Noor Khan Muslim Bin Aqeel Brain-protective mechanisms of autophagy associated circRNAs: Kick starting self-cleaning mode in brain cells via circRNAs as a potential therapeutic approach for neurodegenerative diseases Frontiers in Molecular Neuroscience circRNAs autophagy neurodegeneration nervous system therapeutics |
| title | Brain-protective mechanisms of autophagy associated circRNAs: Kick starting self-cleaning mode in brain cells via circRNAs as a potential therapeutic approach for neurodegenerative diseases |
| title_full | Brain-protective mechanisms of autophagy associated circRNAs: Kick starting self-cleaning mode in brain cells via circRNAs as a potential therapeutic approach for neurodegenerative diseases |
| title_fullStr | Brain-protective mechanisms of autophagy associated circRNAs: Kick starting self-cleaning mode in brain cells via circRNAs as a potential therapeutic approach for neurodegenerative diseases |
| title_full_unstemmed | Brain-protective mechanisms of autophagy associated circRNAs: Kick starting self-cleaning mode in brain cells via circRNAs as a potential therapeutic approach for neurodegenerative diseases |
| title_short | Brain-protective mechanisms of autophagy associated circRNAs: Kick starting self-cleaning mode in brain cells via circRNAs as a potential therapeutic approach for neurodegenerative diseases |
| title_sort | brain protective mechanisms of autophagy associated circrnas kick starting self cleaning mode in brain cells via circrnas as a potential therapeutic approach for neurodegenerative diseases |
| topic | circRNAs autophagy neurodegeneration nervous system therapeutics |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2022.1078441/full |
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