A strategy to identify a ketoreductase that preferentially synthesizes pharmaceutically relevant (S)-alcohols using whole-cell biotransformation

A strategy to identify a ketoreductase that preferentially synthesizes pharmaceutically relevant (S)-alcohols using whole-cell biotransformation

Abstract Introduction Chemical industries are constantly in search of an expeditious and environmentally benign method for producing chiral synthons. Ketoreductases have been used as catalysts for enantioselective conversion of desired prochiral ketones to their corresponding alcohol. We chose repor...

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Bibliographic Details
Main Authors: Saiful F. Haq, Anirudh P. Shanbhag, Subbulakshmi Karthikeyan, Imran Hassan, Kannan Thanukrishnan, Abhishek Ashok, Sunilkumar Sukumaran, S. Ramaswamy, Nagakumar Bharatham, Santanu Datta, Shalaka Samant, Nainesh Katagihallimath
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Microbial Cell Factories
Subjects:
Biotransformation
Chiral alcohol synthesis
Short chain dehydrogenase
Medium chain dehydrogenase
Ketoreductase
Online Access:http://link.springer.com/article/10.1186/s12934-018-1036-2

Internet

http://link.springer.com/article/10.1186/s12934-018-1036-2

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