PE_PGRS33 Contributes to Mycobacterium tuberculosis Entry in Macrophages through Interaction with TLR2.

PE_PGRS represent a large family of proteins typical of pathogenic mycobacteria whose members are characterized by an N-terminal PE domain followed by a large Gly-Ala repeat-rich C-terminal domain. Despite the abundance of PE_PGRS-coding genes in the Mycobacterium tuberculosis (Mtb) genome their rol...

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Main Authors: Ivana Palucci, Serena Camassa, Alessandro Cascioferro, Michela Sali, Saber Anoosheh, Antonella Zumbo, Mariachiara Minerva, Raffaella Iantomasi, Flavio De Maio, Gabriele Di Sante, Francesco Ria, Maurizio Sanguinetti, Giorgio Palù, Michael J Brennan, Riccardo Manganelli, Giovanni Delogu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4792380?pdf=render