Suprachoroidal and Subretinal Injections of AAV Using Transscleral Microneedles for Retinal Gene Delivery in Nonhuman Primates

Suprachoroidal and Subretinal Injections of AAV Using Transscleral Microneedles for Retinal Gene Delivery in Nonhuman Primates

Retinal gene therapy using adeno-associated viruses (AAVs) is constrained by the mode of viral vector delivery. Intravitreal AAV injections are impeded by the internal limiting membrane barrier, while subretinal injections require invasive surgery and produce a limited region of therapeutic effect....

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Bibliographic Details
Main Authors: Glenn Yiu, Sook Hyun Chung, Iris N. Mollhoff, Uyen Tu Nguyen, Sara M. Thomasy, Jesse Yoo, Donna Taraborelli, Glenn Noronha
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Molecular Therapy: Methods & Clinical Development
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050120300139

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http://www.sciencedirect.com/science/article/pii/S2329050120300139

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