<sup>13</sup>C Metabolic Flux Analysis Indicates Endothelial Cells Attenuate Metabolic Perturbations by Modulating TCA Activity

<sup>13</sup>C Metabolic Flux Analysis Indicates Endothelial Cells Attenuate Metabolic Perturbations by Modulating TCA Activity

Disrupted endothelial metabolism is linked to endothelial dysfunction and cardiovascular disease. Targeted metabolic inhibitors are potential therapeutics; however, their systemic impact on endothelial metabolism remains unknown. In this study, we combined stable isotope labeling with <sup>13&...

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Bibliographic Details
Main Authors: Bilal Moiz, Jonathan Garcia, Sarah Basehore, Angela Sun, Andrew Li, Surya Padmanabhan, Kaitlyn Albus, Cholsoon Jang, Ganesh Sriram, Alisa Morss Clyne
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Metabolites
Subjects:
metabolic flux analysis
fluxomics
endothelial metabolism
cardiovascular disease
polyol pathway
pentose phosphate pathway
Online Access:https://www.mdpi.com/2218-1989/11/4/226

Internet

https://www.mdpi.com/2218-1989/11/4/226

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