Extracellular Matrix Rigidities Regulate the Tricarboxylic Acid Cycle and Antibiotic Resistance of Three‐Dimensionally Confined Bacterial Microcolonies

Extracellular Matrix Rigidities Regulate the Tricarboxylic Acid Cycle and Antibiotic Resistance of Three‐Dimensionally Confined Bacterial Microcolonies

Abstract As a major cause of clinical chronic infection, microbial biofilms/microcolonies in host tissues essentially live in 3D‐constrained microenvironments, which potentially modulate their spatial self‐organization and morphodynamics. However, it still remains unclear whether and how mechanical...

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Bibliographic Details
Main Authors: Yiming Han, Nan Jiang, Hongwei Xu, Zuoying Yuan, Jidong Xiu, Sheng Mao, Xiaozhi Liu, Jianyong Huang
Format: Article
Language:English
Published: Wiley 2023-03-01
Series:Advanced Science
Subjects:
bacterial biofilm
matrix stiffness
mechanobiology
metabolism
minimum biofilm elimination concentration
Online Access:https://doi.org/10.1002/advs.202206153

Internet

https://doi.org/10.1002/advs.202206153

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