Potential drug discovery for COVID-19 treatment targeting Cathepsin L using a deep learning-based strategy

Potential drug discovery for COVID-19 treatment targeting Cathepsin L using a deep learning-based strategy

Cathepsin L (CTSL), a cysteine protease that can cleave and activate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, could be a promising therapeutic target for coronavirus disease 2019 (COVID-19). However, there is still no clinically available CTSL inhibitor that ca...

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Bibliographic Details
Main Authors: Wei-Li Yang, Qi Li, Jing Sun, Sia Huat Tan, Yan-Hong Tang, Miao-Miao Zhao, Yu-Yang Li, Xi Cao, Jin-Cun Zhao, Jin-Kui Yang
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
COVID-19
Cathepsin L
Deep learning
Drug prediction
Daptomycin
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022001799

Internet

http://www.sciencedirect.com/science/article/pii/S2001037022001799

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