Alpha-Synuclein Expression in the Oligodendrocyte Lineage: an In Vitro and In Vivo Study Using Rodent and Human Models

In this study, we sought evidence for alpha-synuclein (ASYN) expression in oligodendrocytes, as a possible endogenous source of ASYN to explain its presence in glial inclusions found in multiple system atrophy (MSA) and Parkinson’s disease (PD). We identified ASYN in oligodendrocyte lineage progenit...

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Bibliographic Details
Main Authors: Mehdi Djelloul, Staffan Holmqvist, Antonio Boza-Serrano, Carla Azevedo, Maggie S. Yeung, Stefano Goldwurm, Jonas Frisén, Tomas Deierborg, Laurent Roybon
Format: Article
Language:English
Published: Elsevier 2015-08-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671115001940